PCR children infectious diseases respiratory viruses rhinovirus. In clinical settings, the interpretation of positive PCR tests, particularly in young children and those who live with them, may be confounded. Viral detection is often asymptomatic and occasionally prolonged, especially for bocavirus and rhinovirus. Younger children had longer durations of PCR detection. The mean duration of PCR detection was ≤2 weeks for all viruses and detections of ≥3 weeks occurred in 16% of episodes. Coronaviruses, human metapneumovirus, and influenza A detections were usually symptomatic bocavirus and rhinovirus detections were often asymptomatic. There were 783 viral detection episodes 440 (56%) associated with symptoms. Compared with single person households, individuals living with children experienced 3 additional weeks of virus detection. Children younger than 5 years reported symptoms more often and were more likely to have a virus detected than older participants (odds ratio 2.47, 95% confidence interval, 2.08-2.94 and OR 3.96, 95% CI, 3.35-4.70, respectively). Participants reported symptoms in 23% and a virus was detected in 26% of person-weeks. Viral illnesses were defined as ≥1 consecutive weeks with the same virus detected with symptoms reported in ≥1 week.
The FilmArray polymerase chain reaction (PCR) platform (BioFire Diagnostics, LLC) was used to detect 16 respiratory viruses. Twenty-six households (108 individuals) provided concurrent symptom and nasal swab data for 4166 person-weeks.
This study: (1) describes the viral etiology of respiratory illness by prospectively collecting weekly symptom diaries and nasal swabs from families for 1 year, (2) analyzed data by reported symptoms, virus, age, and family composition, and (3) evaluated the duration of virus detection.
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